Biodegradable Medical Polymers
Working with our partner PolymerPharm, NovoMed has taken steps to enhance the efficacy
of phage therapy via a recently developed technology called amino acid-based biodegradable polymers.
Invented by two distinguished Georgian scientists - Prof. Zemphira Alavidze, PhD and Prof.
Ramaz Katsarava, PhD., biodegrable polymers are applicable in many areas in medicine
including use in wound care, treatment of osteomyelitis and surgical infections.
PhagoBioDerm is a medicated wound dressing acting in drug sustained/controlled release
fashion made of biodegradable and highly biocompatible polymer, containing bacteriophages'
cocktail as an antibacterial agent.
PhagoBioDerm is a biocomposite material based on biodegradable poly(ester amide)
matrix and containing complex of bacteriophages against 5 general suppurative
microorganisms (Pseudomonas aeruginosa, E.coli, Staphylococcus, Streptococcus and Proteus)
as bactericidal substances, and acting in drug sustained/controlled release fashion.
PhagoBioDerm contains also antibiotic ciprofloxacin, painkiller Benzocain and proteolytic
enzymes (a-Chymotrypsin or Trypsin).
Therapeutic effect of the preparation is related to several factors:
- Polymeric film protects the wound surface from intensive moisture losses via
uncontrollable evaporation, and from external actions like mechanical irritation,
microbial invasion, etc. A high biodegradation rate provides a sufficient amount of
polymeric debris (biodegradation products) that accelerate macrophages for their
production of cell growth factors, accelerate the tissue regeneration.
- A-Chymotrypsin (or Trypsin) promotes the sanitation of the wound surface
and erodes polymeric film, thereby providing in that way with sustained/controlled
release of bioactive substances into surrounding tissues.
- Bacteriophages and antibiotic (can be varied) suppress bacterial flora,
bacteriophages suppress the flora resistant to antibiotics.
- Benzocain causes local painkiller effect.
A high therapeutic effect of the preparation is achieved owing to a high local
concentration of active substances for a long period at a low integral dose of the
drug(s) that minimizes possible adverse effects.
PhagoBioDerm is an innovative product and has no analogues in world pharmacy.
It has been developed by a group of Georgian chemists and microbiologists since 1995. PhagoBioDerm
is an anti-microbial, antiseptic, accelerated wound healing remedy. It is a highly efficacious medical
device with a prolonged action used for healing various infected wounds and sores, as well as,
dental gum diseases. It contains biodegradable polymers (composed of naturally occurring and
non-toxic building blocks) and a complex of bacteriophages as bactericidal substances.
R Katsarava, V Beridze, N. Arabuli, D. Kharadze, C.C.Chu, C.Y. Won
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Synthesis and Characterization of Novel Biodegradable Unsaturated Poly(ester amide)s
Received 16 June 2004; accepted 4 August 2004 DOI: 10.1002/pola.20463
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In-vivo biocompatibility evaluation of stents with a new biodegradable elastomeric and functional polymer.
Journal of Coronary Artery Disease, 13(4), 237-241 (2002).
Kalistrat Markoishvili, MD, George Tsitlinadze, MD, Ramaz Katsarava, PhD, J.Glenn Morris, Jr., PhD and Alexander Sulakvelidze, PhD
A novel sustained release matrix based on biodegradable poly(ester amide)s and impregnated with bacteriophages and an antibiotic shows promise in management of infected venous stasis ulcers and other poorly healing wounds.
International Journal of Dermatology, 41 453-458 (2002).
G. Tsitlanadze, M. Machaidze, T. Kviria, N. Djavakhishvili, C.C. Chu, R. Katsarava.
Biodegradation of amino-acid-based poly(ester amide)s: in vitro weight loss and preliminary in vivo studies.
J. Biomater. Sci. Polymer Edn, 15(1), 1-24 (2004).
G. Tsitlinadze, T. Kirviria, R.Katsarava
In-vitro enzymatic biodegradation of amino based poly(ester amide)s and biomaterials
Journal of Materials Science: Materials in Medicine 15, 185-190 (2004).
D. Jikia, N. Chkhaidze, E. Imedashvili, I. Mgaloblishvili, G. Tsitlanadze, R. Katsarava, J. Glenn, Morris, Jr., Alexander Sulakvelidze
The use of a novel biodegradable preparation capable of the sustained release of bacteriophages and ciprofloxacin, in the complex treatment of multidrug-resistant Staphylococcus aureus-infected local radiation injuries caused by exposure to Sr90.
Clinical and Experimental Dermatology, 30, 23-26 (2005).
Guo K., Chu C. C., Chkhaidze E., Katsarava R.
Synthesis and Characterization of Novel Biodegradable Unsaturated Poly(Ester-Amide)s
J. Polym. Sci. Part A: Polym. Chem. 43, 1463-1477 (2005).
I. Legashvili , N. Nepharidze, R. Katsarava, B. Sannigrahi, I. M. Khan
Non-covalent nano-adducts of co-poly(ester amide) and poly(ethylene glycol): preparation, characterization and model drug-release studies.
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Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity
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Monitoring the in Vitro Enzyme-Mediated Degradation of Degradable Poly(ester amide) for Controlled Drug Delivery by LC-ToF-MS
Kristin M. DeFife, Kathy Grako, Gina Cruz-Aranda, Sharon Price, Ron Chantung, Kassie Macpherson, Ramina Khoshabeh, Sindhu Gopalan andWilliam G. Turnell
Poly(ester amide) Co-polymers Promote Blood and Tissue Compatibility
Journal of Biomaterials Science 20 (2009) 1495-1511
Jiayi Yu, Fei Lin, Panpan Lin, Yaohua Gao and Matthew L. Becker
Phenylalanine-Based Poly(ester urea): Synthesis, Characterization, and in vitro Degradation
dx.doi.org/10.1021/ma401752b | Macromolecules 2014, 47, 121?129
Mikael Trollsas, Bozena Maslanka, Nam Pham, Qing Lin, Syed Hossainy, Shaw Ling Hsu and Michael Huy Ngo
Polyesteramide Coatings for Drug Eluting Stents: Controlling Drug Release by Polymer Engineering
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Biocompatibility Study at Stratec
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New unsaturated biodegradable poly(ester amide)s composed of fumaric acid, L-leucine and , -alkylene diols
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G. Jokhadze1, M. Machaidze, H. Panosyan, C. C. Chu, R. Katsarava
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J. Biomater. Sci. Polymer Edn, 18(4), 411-438 (2007).
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Non-conventional polymers composed of naturally occurring a-amino acids
Journal of Characterization and Development of Novel Materials, 2(3-4), 325-342 (2011).
R. Katsarava, Z. Gomurashvili
Biodegradable Polymers Composed of Naturally Occurring ?-Amino Acids.
Handbook of Biodegradable Polymers - Isolation, Synthesis, Characterization and Applications, Lendlein, A. and Sisson, A., Eds., Wiley-VCH, Verlag GmbH & Co. KGaA. Ch. 5, 107-131 (2011).
S. Kobauri, N. Zavaradshvili, M.Dgebuadze, D. Tugushi, R.Katsarava
Novel Hydrophobic Biodegradable Ester-Polymers Obtained via Azlactone Chemistry
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N.Zavradashvili, G.Jokhadze, M. Gverdtsiteli, G.Otinashvili, N.Kupatadze, Z.Gomurashvili, D. Tugushi, R. Katsarava
Amino Acid Based Epoxy-Poly(Ester Amide)s - a New Class of Functional Biodegradable Polymers: Synthesis and Chemical Transformations
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Cell compatible arginine containing cationic polymer: one-pot synthesis and preliminary biological assessment
Springer Book Series-Advances in experimental medicine and biology: Infectious Diseases and Nanomedicine (i press, 2014).